Brain Spect Evaluation of Psychiatric Dysfunctions in Severe Atopic Dermatitis.
Introduction: Severe atopic dermatitis (AD) usually has a psychiatric component that may influence the course of the cutaneous symptoms. Functional neuroimaging could evidence brain dysfunctions in this kind of patients.
Objective: Evaluate the presence and characteristics of cerebral perfusion changes in severe AD patients using SPECT.
Materials and methods: 11 severe AD patients were subjected to clinical psychiatric evaluation and 99mTc-ECD SPECT.
Results: 90.3% of the patients presented a generalized anxiety disorder, 63.6% an obsessive compulsive disorder and 63.6% a depression.
The 11 patients presented perfusion changes that prevailed at the prefrontal cortex. The alterations were concordant with the patterns described in those patients in which anxiety disorders and depression coexist.
Conclusions: We demonstrate the frequent presence of perfusion changes in severe AD patients with psychiatric symptoms and describe their characteristics by means of a neuroimaging method.